They uncovered a clue to a potential mechanism when they discovered a circadian variability in the local vascular response to hormones that affect blood pressure. In addition, other recent studies had found that circulating concentrations of some steroids undergo circadian variability and examples of hormonal phase-shifting of circadian genes in peripheral organs were beginning to emerge. This was considered interesting because steroid hormones and vitamins regulate developmental and physiological processes by activating intracellular members of the nuclear receptor superfamily, which function as ligand-dependant DNA-binding transcription factors.
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